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Phase 1 trial of temsirolimus in combination with irinotecan and temozolomide in children, adolescents and young adults with relapsed or refractory solid tumors: a Childrens Oncology Group Study

Therefore, mitochondrial dysfunction prevents cells from meeting their energy requirements and involves impairment of neuronal communication, cellular resilience, and hippocampal neurogenesis, which leads to mood and psychiatric disorders (Perkins et al., 1997

On the antioxidant hypothesis with regard to arteriosclerosis

A separate study showed that TSA reduced Propionibacterium acnes-induced expression of pro-inflammatory factors (IL-1, IL-8, and TNF-) and activation of key proteins [TLR2, NF-B and intercellular adhesion molecule 1 (ICAM-1)] in the TLR2/NF-B signaling pathway in THP-1 cells, suggesting that TSA alleviates inflammation by blocking this pathway (41)

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