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Second, translational development should focus on dual-functional nanocarriers incorporating A-targeting peptides and RVG29 brain-homing peptides, delivering GPX4 activators or iron chelators with pH/ROS-responsive release to ensure lesion-specific delivery and avoid neurotransmitter synthesis impairment from non-specific iron depletion

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Ferroptosis-related detection Mitochondrial membrane potential detection Mitochondrial membrane potential was measured by fluorescence microscopy of cells using Mitochondrial Membrane Potential Assay Kit with TMRE (Beyotime, China)

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Peptoids are among a class of biochemicals known as biomimetics, or molecules that mimic the behavior of biological molecules