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However, in Wilson disease, the process is impaired and excess copper is initially deposited in the liver where it damages liver cells

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Physical-chemical aspects of protein corona: relevance to in vitro and in vivo biological impacts of nanoparticles

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Neutrophil depletion attenuates acute renal injury after exhaustive exercise in mice

This action is consistent with its known mechanism as a tetracycline derivative that suppresses activated microglia, the resident immune cells of the central nervous system (Tikka et al., 2001)