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With increasing CSA-13 concentration and increasing incubation time in blood, we observe a decrease in CFU/mL of this bacterium, but we assume that the extension of incubation time may correlate with a reduction in the therapeutic dose of CSA-13

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Exclusion criteria should include severe acidosis, fulminant hepatic failure, renal failure requiring dialysis, recent SGLT2 use, diabetic ketoacidosis, refractory shock, pregnancy, uncontrolled ileus, and patients admitted for post-operative monitoring

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It suggests that the appropriate regulation of redox homeostasis is a critical consideration and is instructive to the clinical application of NAC