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High doses of Vitamin B6 can cause peripheral neuropathy, a condition characterized by nerve damage, leading to numbness and tingling in the extremities[234]

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(I've described my distaste for the entire concept of antidotes in a previous column, arguing that the term leads to muddy thinking and failure to weigh critically whether or not a specific intervention is indicated in individual cases.) Dr Juurlink is careful to point out that the vast majority of VPA overdose cases will not need a carbapenem because most patients improve with routine treatment

It can therefore be assumed that TRP supplements will increase flux through the TRP-KYN and TRP-IND pathways, increase the production of uremic toxins, and worsen the disease

Those increases in power output were similar to those previously reported with acute intake of 4.5 g GPLC

J Endocrinol Invest (2013) 36:1520