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Thus, 30-days application of erinacine A and S attenuated cerebral plaque loading by inhibiting plaque growth, diminishing glial cell activation, and promoting hippocampal neurogenesis in transgenic mice as Alzheimers disease model

Sohn EJ, Kim JH, Oh SO, Kim JY

Furthermore, GDF15 has been implicated in disorders associated with central sensitization, highlighting its relevance to FM pathophysiology 11

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The size and burden of mental disorders and other disorders of the brain in Europe 2010

This decreased sensitivity is due to the cold tumor effect that CAFs confer, caused by the recruitment of Tregs via TGF, MDSCs via complement signaling, and CXCL16 and CTL exclusion ( The key role played by CAFs in TNBC opens the door to new therapeutic strategies that target CAFs, such as fibroblast grow factor receptor (FGFR) blockade with erdafitinib