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[105] IL-12 was even found abnormally elevated in the serum of secondary progressive MS patients

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These include a number of proteins found at high abundance in human serum that are likely to be contaminants, for example complement component C1Q and apolipoproteins L1 and L2 (Supplementary Data 3b)

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Several potential mechanisms have been proposed, including chelation by reductants (such as flavins or NADPH), direct electron transfer via reductases (e.g., STEAP3), and lysosomal degradation during ferritinophagy [116]