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Interestingly, polymorphisms in genes encoding acetaminophen-metabolizing enzymes might be responsible for dramatic ethnic and racial differences in APAP metabolism and toxicity [109113]

321 Recognition-memory impairment in an AD mouse model (5xFAD) can be accelerated by high-fat obesogenic diet by increasing blood levels of the metabolite N-acetylneuraminic acid (NANA), which results in systemic immune exhaustion

System Xc -, located on the cell membrane, is a heterodimer linked by disulfide bonds and contains the heavy chain subunits solute carrier family 3 member 2 and solute carrier family 7 member 11 (SLC7A11) (60)