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Fe-S clusters play a crucial role in this process 76 , as the mitochondrial MOCS1A enzyme, which coordinates the first step in Moco biosynthesis, binds two [4Fe-4S] clusters per monomer 77

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The group further showed that lower levels of ROS were associated with increased free radical scavenging systems and that pharmacologic depletion of these scavengers significantly decreased clonogenicity and resulted in radiosensitization of CSCs