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Physiologically, and similar to apoptosis of nucleated cells, eryptosis occurs to ultimately eliminate damaged senescent, and damaged or dysfunctional mature erythrocytes from the circulation [204]

10.1016/j.jbc.2023.105457 98 PrudovaA.BaumanZ.BraunA.VitvitskyV.LuS

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The occurrence and development of different diseases are associated with abnormal GSH metabolism through different mechanisms: Glutathione dynamics during sepsis Sepsis is characterized by severe redox imbalance, and glutathione plays a key role in combating oxidative and nitrosative stress