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A distinctive pathological feature of ALS is the mislocalization and aggregation of phosphorylated TDP-43 (pTDP-43), a nuclear RNA-binding protein encoded by TARDBP

PDX1 is important for the development of pancreatic cells through maturation of cells and also via duodenal differentiation [63]

Yao J, Petanceska SS, Montine TJ, Holtzman DM, Schmidt SD, Parker CA, Callahan MJ, Lipinski WJ, Bisgaier CL, Turner BA, Nixon RA, Martins RN, Ouimet C, Smith JD, Davies P, Laska E, Ehrlich ME, Walker LC, Mathews PM, Gandy S

Early signs include tingling, pins and needles, or numbness, usually starting in the hands and feet

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Quantile-dependent expressivity and gene-lifestyle interactions involving high-density lipoprotein cholesterol