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Author contributions CY: Formal Analysis, Writing review & editing, Methodology, Validation, Writing original draft, Software, Data curation, Conceptualization

[ 419 ] Idiopathic Pulmonary fibrosis (IPF) is a chronic and advancing disease featuring diffuse inflammation, interstitial fibrosis, and the distortion of the lung framework, resulting in extensive impairment and dysfunction of the lungs

Many transcription factors and DNA-binding proteins are redox regulated by TRX, including NFKB, AP-1 , PEBP2/AML-1 , and p53

Risks and Side Effects While IGF-1 does have some important roles, on the other hand it has some negative effects when levels rise too high

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Increased plasma values of thyroid hormones in circulation activate negative feedback loop and inhibit release of TSH (54, 55)