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SARS-CoV-2 infection could impact the complex gut community and drive immunological changes

Low oral bioavailability, limited intestinal permeability, and extensive presystemic processing may substantially limit systemic exposure and complicate doseresponse interpretation across studies (Liu et al., 2005

While local GABA concentrations are generally negatively related to stimulus-induced cortical activity, positive correlation between glutamate concentrations and inter-regional activity relationships has been reported (Duncan et al., 2014)

For example, HER2/neu-specific effector CAR T cells caused fatal acute respiratory distress syndrome in one patient owing to a low level of expression of the target antigen in the lung 102

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Moreover, G289A and T337I mutations are located proximal to the ATP-binding pocket of the C-terminal domain, G289A would cause steric conflict with Ser293, and T337I would cause a hydrophobic patch on the protein surface and reduce protein solubility