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Nevertheless, it is suggested that intestinal microbiota might play a certain role in the pathogenesis and progression of the disease (66)

Through the cystine/glutamate antiporter (System X c - ), a heterodimer formed by the disulfide bonding of the light chain subunit (SLC7A11) and heavy chain subunit (SLC3A2), intracellular glutamate is exchanged for extracellular cystine at a 1:1 ratio (103), and cystine entering the cells is reduced to cysteine (the most abundant cellular antioxidant) (104)

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Such disruptions result in decreased ATP production and compromised mitochondrial function [28]

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Moreover, the review highlights its immunomodulatory properties to inform future antiviral and anticancer drug development and therapeutic strategies