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Thus, the early identification, assessment and treatment of symptoms such as pain, dyspnea and uncontrollable coughing, as well as any other symptom related with disease progression, in both the physical and psychosocial sphere, is important.80 It is therefore recommended that palliative care be considered an integral part of the overall treatment of IPF (consistent recommendation, very low quality evidence)

Clinical studies have demonstrated that topical niacinamide improves the appearance of aging facial skin, including reductions in fine lines, wrinkles, yellowing, red blotchiness, and hyperpigmented spots, while also enhancing barrier function

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In summary, from modulating microglial polarization and neutralizing pro-inflammatory cytokines, to targeting immune checkpoints and astrocyte-derived inhibitory pathways, immunomodulatory strategies offer multifaceted approaches to disrupt the ferroptosisinflammation interplay

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However, only pimitespib, an oral inhibitor developed by Taiho Pharmaceutical, was approved in Japan in 2022 for gastrointestinal stromal tumors, and it is currently the focus of a phase I study for the treatment of solid tumors in the EU and USA [7, 8]