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Introduction Polycystic Ovarian Syndrome is a complex multi-spectrum disease involving the endocrine, metabolic and reproductive systems with an incidence of 6-21% ( Basis of Folliculogenesis and Its Disturbances in PCOS Folliculogenesis refers to the pathway of ovarian follicle development from primordial germ cells to become mature oocytes ( Figure 1 )

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In line with the 3Rs policy (replacement, reduction, refinement), drug toxicity in humans is aimed to be detected across the drug discovery process without relying exclusively on animal studies

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ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose

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