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Curcumin possesses antioxidative properties and are shown to inhibit oxidative stress [33, 34] and generation of ROS in vivo [46]

This leads to the development of (1) hyponatremia, (2) hypokalemia, (3) metabolic alkalosis, (4) low urine sodium, (5) high urine potassium excretion, and (6) high urine osmolality

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(1983) ip micromelia, syndactyly, hydronephrosis and subcutaneous haemorrhage in the face, fore- and hind paws

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In this context, Du et al., noted loss of tissue resident macrophages in colon biopsies from patients with ulcerative colitis, that was accompanied by decreased superoxide dismutase 2 expression (an important antioxidant) in the macrophages [3]