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Nonetheless, many clinical investigations are limited by short follow-up durations, small sample sizes, heterogeneous formulations, and reliance on surrogate endpoints, such as variations in bacterial diversity or inflammatory markers, rather than definitive clinical outcomes, thereby limiting the robustness of current conclusions (2, 4)

& Vercellotti, G.M

doi: 10.1007/s11306-015-0816-5 188 KennedyGSpenceVAMcLarenMHillAUnderwoodCBelchJJ

Freezing reconstituted peptide solutions can cause ice crystals to form that damage the protein structure

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Melanocytes in vitiligo are thought to be damaged by an accumulation of reactive oxygen species to destroy the structural and functional integrity of their DNA, lipids, and proteins