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This triple mechanism explains why clinical trials showed weight loss results exceeding all previous medications in this class

In addition to the non-targeting TCB control, an IgG containing the MAGE-A4-TCB tumor binding arm with a different CD3 binding arm of low affinity or an active Fc domain would have been helpful to discern on/off-target effects from non-specific CD3-mediated effects

Further studies under controlled thermal stress are warranted to confirm efficacy and establish doseresponse relationships

Exp Gerontol 45: 173179, 2010