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Moderate deficiency causes peripheral neuropathy, characterized by numbness, tingling, and weakness in the hands and feet

This adds to the difficulty in reconciling MS under a single pathophysiological umbrella, but also has implications for therapeutic design: this cytodegenerative component is not expected to respond to current anti-inflammatory disease-modifying drugs targeting acute/adaptive peripheral autoimmunity

All this to say, these are competitive results however the rates of diarrhea and vomiting could be a problem if they continue to develop the 6mg dose, and for Kailera, they need to conduct trials in the United States and elsewhere