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In HBECs induced by 20% CSE, ROS levels increased significantly, ATP content decreased, and PINK1 and Parkin proteins increased, indicating that mitochondrial function was impaired, leading to excessive activation of mitophagy

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Some of the fragments, for which X-ray structures were obtained, were found in the doorstop pocket expected to be critical for TGR inhibition and adjacent to the NADPH binding site (Fig