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I trust that the insights and findings presented in this manuscript will be of value to the medical community and to the individuals who grapple with this challenging condition

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Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences Paul Flechsig Institute - Center of Neuropathology and Brain Research Paul Flechsig Institute - Center of Neuropathology and Brain Research, Medical Faculty Paul Scherrer Institute Pazhou Lab Peking Union Medical College Peking Union Medical College Hospital Peking University First Hospital Peking university Academy for Advanced Interdisciplinary Studies Peking University Cancer Hospital & Institute Peking University Cancer Hospitals & Institution peking university first hospital Peking University Fourth School of Clinical Medicine, Beijing Jishuitan Hospital Peking University Peoples Hospital Peking University People's Hospital Peking University Shenzhen Hospital Peking University Third Hospital PEKING UNIVESITY SHENZHENG HOSPITAL Peng Cheng Laborat Peng Cheng Laboratory Penn State University Pennington Biomedical Research Center Pennsylvania State University Pennsylvania State University College of Medicine Pennsylvania State University College of Medicine and Milton S