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Bibcode:2020ChRv..120.4707F

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ORF9b suppresses the type I interferon immune response by interacting with the mitochondrial import receptor subunit TOM70

These conditions include cardiovascular disease (such as coronary artery disease, stroke, life-threatening arrhythmias, congestive heart failure, or untreated hypertension), advanced arteriosclerosis, hyperthyroidism, glaucoma, psychiatric agitation or psychosis, recent or concurrent MAOI therapy (within 14 days), history of drug abuse, pregnancy, breastfeeding, pediatric patients under 16, and concurrent use of other weight-loss medications