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Description

It is important to emphasize how this kind of degeneration differs from OHC apoptosis, which features cell shrinkage, membrane blebbing, karyorrhexis, and apoptotic bodies

Together, this suggests that the functions of cholesterol in ferroptosis resistance could be multifaceted

Interestingly, inhibition of CIA was observed even when ICOSL blocking antibody was given after the onset of disease (114)

doi: 10.3390/cells11182857 48 ChavisPShinozakiHBockaertJFagniL

doi: 10.1136/gut.19.6.474

Tor/mTOR is a serine/threonine kinase with a molecular weight of approximately 289 kDa and is classified within the phosphoinositide 3-kinase-related kinase (PIKK) family owing to structural similarities in its catalytic domain