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Description

Identification of the serine biosynthesis pathway as a critical component of BRAF inhibitor resistance of melanoma, pancreatic, and non-small cell lung cancer cells

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Some researchers also track NAD+ metabolite levels via urinary nicotinamide excretion to confirm functional NNMT inhibition, though this is not standard practice

Free Radic Biol Med (2017) 111:196208

70 PARP1 is the best characterized and most studied member that is involved in repairing single strand breaks (SSBs)

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