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The compounds quinolinium scaffold mimics nicotinamides structure, allowing it to compete for the NNMT active site while avoiding interactions with other enzymes

doi: 10.1016/j.cub.2020.09.068 12 SassettiEClausenMHLaraiaL

It also inhibits the expression of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G6Pase), key enzymes in gluconeogenesis (Hardie et al

The effect of long-term homocysteine-lowering on carotid intima-media thickness and flow-mediated vasodilation in stroke patients: a randomized controlled trial and meta-analysis

Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas: final report