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doi: 10.1016/j.carbpol.2022.120153 218 BosiABanfiDBistolettiMMorettoPMoroECremaFet al

Simultaneously, anti-inflammatory cytokines such as TGF-, GDF-5, GDF-6, IL-4, and IL-10 are also present in the degenerative environment and can, to some extent, delay degeneration and alleviate pain (Wang et al., 2016), with their balance potentially closely related to the polarization state of macrophages (Yamamoto et al., 2022