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On an immunomodulatory level, anti-inflammatory factors secreted by the amniotic membrane (e.g., SLPI/elafin) synergize with MenSC-derived paracrine cytokines such as IDO, PGE 2 , and TGF-, promoting the polarization of macrophages from the pro-inflammatory M1 phenotype to the regenerative M2 phenotype

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Serine can be converted to glycine by SHMT1 in the cytoplasm or SHMT2 in the mitochondria [26,27,28]