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It is specifically characterized by inflammation, demyelination, and neuronal loss and manifests with a range of neurological symptoms including numbness, tingling, vision impairment, cognitive impairment, and bladder and bowel dysfunction (Tafti et al., 2024)

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As shown in Figure 12.7 , the concentration of ATP in the RBC (~2 mmol/L) normally suppresses the activity of PFK-1