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This is mainly due to the functioning of the pineal gland deteriorating with increased age and a reduction of hormone circadian rhythm amplitude

GHK-Cu still helps deep wrinkles through increased collagen and improved skin thickness, but expectations should be tempered

10.1007/s10787-017-0330-7 42 MasnecS.KokotA.ZlatarM.KalauzM.KunjkoK.RadicB.et al (2015)

Patch dosing will be measured differently (typically in milligrams per day released through the skin) and will require entirely new comparison frameworks