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The discovery of additional pockets on the target enzyme, target optimization (identifying substitutable targets), and the use of computational tools may offer new strategies

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T cell progenitors differentiate into CD4 and CD8 double negative thymocytes ( DP thymocytes, in turn, recognize self-antigens and MHC molecules (class I or class II) on the surface of cortical thymic epithelial cells via their TCRs and undergo thymic selection

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