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It has also been observed in vitro that SCs and neurites prefer to travel towards softer stiffness substrates 35,36 , suggesting that materials within the lumen which are stiffer than the surrounding tissues can be inhibitory to nerve growth

Ware, D., Jiang, Y., Lin, W., & Swiatlo, E

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Week 1-2: Adjustment period What happens: Skin adapts to retinol (may see some peeling, redness) Peptides begin signaling collagen production Texture may worsen before improving (retinol purge) What to do: Stick with routine unless severe irritation Reduce retinol frequency if needed Increase moisturizer Week 4-6: Initial improvements What you'll notice: Smoother skin texture Reduced breakouts (if acne-prone) More even tone Skin feels firmer Less irritation as skin adjusts Peptide + retinol advantage: Smoother, more hydrated texture than retinol alone