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Impaired mitochondrial function induced by viral infection, partially caused by the production and accumulation of ROS, might contribute to the low TCA cycle activity [55]

Without sufficient oxygen being delivered from red blood cells, your muscles will feel weak

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A recent review summarized that sepsis can impair oxidative phosphorylation, increase mitochondrial reactive oxygen species, disturb mitochondrial dynamics, and compromise mitochondrial quality control, thereby promoting tissue damage and multi-organ failure ( Oxidative stress is a key upstream driver of these mitochondrial lesions