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6.2.1.3 LRRK2 kinase inhibitors: from mechanism to clinical translation As an important direction in potential treatment strategies for PD, inhibitors targeting the LRRK2 kinase have attracted significant attention in recent years

High stress increases mast cell activation and increases histamine levels

A single exposure of doxorubicin between 0 and 50 M, yields minimal cytosolic GSH depletion (2.5% maximum decrease), which recovers within the prescribed time-span (Fig

Mutation of Tyr 180 to Ala reduced activity by ~80%, even though the side chain is far from the active site, so it is unlikely that Tyr 180 is involved in catalysis