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This nanofibrous dressing promoted epithelial regeneration and reduced bacterial colonization, indicating its utility in infection-prone wounds

Although the use of primary brain endothelial cells and/or co-culture with other cells would provide a physiologically more relevant environment, bEND.3 cells consistently show a stable barrier function and thus have been widely used in previous studies on BBB permeability to therapeutics 35

Observe the behavior, weight changes and death of the animals to determine the maximum tolerated dose (MTD) or median lethal dose (LD50)

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Several randomized, placebo-controlled trials indicate that metformin therapy leads to a progressive decline in vitamin B12 levels and can cause physiologically significant deficiency (153)