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Handling and Stability Risks Improper handling exposure to light, heat, repeated freeze-thaw cycles, or strongly alkaline conditions can degrade the peptide or disrupt copper coordination, producing experimental variability that is sometimes mistaken for biological inconsistency

The side effects of unapproved oral or injectable peptides are unknown, but they can be contaminated with heavy metals or be of questionable purity

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As a result, direct oral GSH administration does not result in significant systemic elevation of GSH levels, curbing its utility in treating neurodegenerative diseases