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There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision

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AOD-9604 the C-terminal 16-amino-acid fragment of human growth hormone (residues 176-191) with a stabilizing tyrosine at position 177 made it further through FDA-track clinical development than almost any other research peptide in this class