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Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages

PubMed Central , Clinical and Experimental Pharmacology & Physiology , vol

Exogenously expressed WT RABGAP1 restores levels of C99, but a GAP-deficient RABGAP1 mutant does not To demonstrate the specificity of the phenotype observed upon RABGAP1 KD, a complementation experiment was carried out to test whether re-introduction of RABGAP1 could recover the loss of C99 observed in RABGAP1 KD i3 neurons (Fig