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Effect of flow on targeting and penetration of angiopep-decorated nanoparticles in a microfluidic model blood-brain barrier

Studies involving approximately 900 participants consistently demonstrated fat loss without changes in IGF-1, preserved glucose homeostasis despite fat reduction, absence of anabolic tissue growth effects, and safety profile comparable to placebo

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Genetic interactions correlated with prognostic genes, and TIDE and ESTIMATE analyses suggested higher tumor immune evasion probability in the high-risk group, providing a rationale for immunotherapy