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The proton gradient yielded from nutrient metabolism is tapped by NNT to drive the transfer of a hydride from NADH to NADP +

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Table 1 exhibits the advantages and disadvantages of synthetic and biological ligands

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Another example of a primary astrocytopathy is the frontotemporal lobar degeneration or Picks dementia, leading to progressive loss of memory, primary progressive aphasia, and social misbehaviour