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Disclosures: Haya Omeish: Nothing to Disclose, Austin Mueller: Nothing to Disclose, Syed-Mohammed Jafri: Takeda: Speaking and Teaching, Gilead: Speaking and Teaching, Abbvie: Speaking and Teaching, Ironwood: Advisor, Intercept: Speaking and Teaching, Dilip Moonka: Nothing to Disclose 617 A PHASE 1/2A SINGLE-CENTER RANDOMIZED PLACEBO-CONTROLLED STUDY OF ORAL IDEBENONE TO TREAT METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS Toby Bradford 1 Natalie Torok 1 , 1 Stanford University Background: Metabolic dysfunction-associated steatohepatitis (MASH) is one of the leading indications for liver transplantation

Intravenous (IV) infusion was used in earlier dose-escalation studies

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doi: 10.1016/j.mehy.2019.109245

To remove chlorine from lipid head groups, a 10-fold molar excess of DTT (Dithiotreitol) or GSH (reduced glutathione) (5.17 mol) was added to 517 nmol total lipids, and the vesicles were incubated for 10 min at 37 C with shaking at 600 rpm