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Notably, certain plant-derived metabolites activate neuroprotective signaling pathways, such as the MAPK/NF-B system, (Md et al., 2021), and interact with estrogen receptor beta (ER), a known regulator of synaptic plasticity and neuroprotection ( 4.6 Overcoming challenges in translating natural compounds into clinical applications Despite promising findings, translating the therapeutic potential of natural compounds into clinical practice presents several key challenges

ALS is recognised as a multisystem neurodegenerative disorder, meaning that many patients also show non-motor symptoms including executive, behavioural and speech issues

Most ototoxic drugs have at least additive ototoxic interactions

Rather, cycloheximide chase assays showed a distinct biphasic post-translational decay of different Vangl1 forms, whereby unphosphorylated Vangl1 is rapidly degraded while there is an aberrant stabilization of the phosphorylated form

Environmental Protection Agency (EPA) as wastewater composed of wash water from kitchen, bathroom, and laundry sinks, tubs, and washers can be used for a number of secondary purposes, including water for cooling systems

Discussion MSC therapy has moved from an experimental curiosity to a credible onco-fertility strategy over the past 15 years