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The organic layer was washed with brine (60 mL), dried with MgSO 4 , the solvent was concentrated to give an oil which was further evaporated in vacuo (0.1 mm Hg) for 14 h at RT to remove 3-fluoro-azetidine to give an oil (1.88 g, approx 4.1 mmol, purity approx 70% by LCMS)

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the antibody and/or the effector can be derivatized to expose or attach additional reactive functional groups