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Prolonged activation of inflammatory pathways in astrocytes and microglia promote demyelination, while their inhibition has the potential to support remyelination in rodents (Jha et al., 2010

Dimers enhance activity by linking two molecules of artemisinin, such as a 2-5-fold increase in anti-malarial activity and stronger inhibition of the PI3K/Akt pathway, which can overcome tumor resistance (apc et al., 2021

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As such, it might be reasonable to select an agent on the basis of a reasonable safety profile