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This broad regulatory activity includes upregulation of tissue repair genes, collagen synthesis pathways, antioxidant defense systems, and anti-inflammatory signaling networks, alongside simultaneous downregulation of genes associated with tissue destruction, inflammation, and fibrosis

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Several etiological factors have been described in the pathogenesis of MS, such as altered immune function, genetics, and environmental factors (Anwar et al

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These simulations indicate that within highly confined matrices, such as those encountered in vivo, the force resulting from the pressure drop across the cell dominates over the total shear force [230]