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232,233 In addition to pathways involved in iron metabolism, several other molecular pathways have also been implicated in ferroptosis, including the guanosine triphosphate cyclohydrolase 1/tetrahydrobiopterin (GCH1/BH4) axis, 234 the cysteine/glutathione/glutathione peroxidase 4 (GSH/GPX4) axis, 235,236 and the ferroptosis suppressor protein 1/coenzyme Q (FSP1/CoQ) axis

Data were imputed by random draw from a normal distribution with default parameters: 0.3 width and 1.8 downshift

This property is of special interest in studies focusing on microvascular repair, ischemia, and circulatory regulation under chemically induced injury or surgical conditions

Brett Brechner, DO, is our medical director

These substitutions were capable of altering the specificity of individual substrates for their cognate kinases in predictable ways, an effect that was driven largely, but not completely, by alteration of the K M values (Extended Data Fig

We thank Shuyun Tian for the assistance in the early stage of the project