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Disclosure of interest: nothing to discloser E-Posters - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.01 - ACUTE MANAGEMENT - Neither thrombolysis nor thrombectomy P2109 - ESOC25-1903 TRIIODOTHYRONINE TREATMENT REDUCES STROKE VOLUME AND IMPROVES NEUROLOGICAL FUNCTION IN A MOUSE MODEL OF ISCHEMIC STROKE Daniel Ullrich 1,2 , Heike Heuer 2,3 , Steffen Mayerl 2,3 , Dagmar Fhrer 2,3 , Christoph Kleinschnitz 1,2 , Friederike Langhauser 1,2 1 Department of Neurology, University Hospital Essen, Germany, Essen, Germany, 2 Center for Translational Neuro- and Behavioural Sciences (C-TNBS), University Hospital Essen, Germany, E, Germany, 3 Department of Endocrinology, Diabetes and Metabolism, University Hospital Essen, University Duisburg-Essen, Germany, Essen, Germany Background and Aims: Thyroid hormones affect the central nervous system's response to various stimuli such as ischemic stroke

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Eight different isoenzymes of GPxs exist, differing in their localization and specificity for phospholipid peroxides, cholesterol peroxides and others

4) in treatment responders, changes to serum GSSG levels were positively correlated with reductions in both the PANSS total score and positive symptom score, and 5) GSSG may be a predictor for clinical symptom improvement