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Cardiovascular tissues are particularly sensitive to the compound 19

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To verify if the increased expression of GCLC , GSS , and GSR had a functional impact on the activity of the GSH pathway, we measured total intracellular glutathione levels and ratio of reduced (GSH) to oxidized (GSSG) glutathione after 24 hours of BDG exposure ( Figure 4D )

These groups have in common a similar heterocyclic ring structure with a variety of substituents ( Figure 243 )

Cardiomyopathy in fumarylacetoacetase deficiency (hereditary tyrosinaemia): a new feature of the disease