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found that ACSL4 gene knockout could attenuate ischemic brain injury while over-expression aggravated IS (Doll and Conrad, 2017

BMJ (Clinical research ed)

The frequency of drug-related hepatic injuries, including from NSAIDs, was found to be different in Spain and France suggesting that several factors besides the NSAIDs, such as drug use patterns and/or genetic and environmental factors, may be important 36

The tspA/tpsB locus evolved in the hyperinvasive lineages with the appearance of repeated N-terminal-truncated tpsA genes ( tpsC cassettes) and Immunity Open Reading Frames (IORFs), which are absent in cc53 (Mullally et al., 2021)