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38 Mendelian randomisation analyses did not find evidence for a causal association between circulating erythritol and coronary artery disease, diabetes, fasting glucose, eGFR, or chronic kidney disease, nor was any evidence found that the evaluated cardiometabolic and anthropometric traits significantly influenced erythritol concentration

On the therapeutic side, a recent clinical study on BC survivors found that chronotype-tailored light therapy, which can modulate melatonin production, significantly reduced fatigue and improved sleep quality 198

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4.2 Oxidative stress and mitochondrial dysfunction Renal energy metabolism depends heavily on oxidative phosphorylation, and in CKD, mitochondrial dysfunction and oxidative stress form a vicious cycle that exacerbates tissue injury